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The Yasui procedure is a specialized surgical intervention primarily designed to correct complex congenital heart defects, particularly those affecting the right ventricle. This technique is a modification of the classical bidirectional Glenn procedure, aimed at enhancing the surgical outcomes for patients with single ventricle physiology. During the procedure, the surgeon establishes a connection between the superior vena cava and the right pulmonary artery, facilitating improved oxygenation of the blood. The Yasui procedure is particularly useful for patients with conditions such as hypoplastic left heart syndrome or other forms of single ventricle anatomy, where normal heart function is compromised. One of the critical aspects of the procedure involves creating an anatomically favorable pathway for blood flow, thus optimizing the hemodynamics within the pulmonary and systemic circulations. The Yasui technique often incorporates the use of a modified blalock-taussig shunt, allowing for greater regulation of blood flow to the lungs while reducing the pressure load on the right heart structures. This approach is markedly different from traditional palliation methods, as it seeks not only to relieve symptoms but also to provide a more definitive anatomical solution for long-term management of congenital heart defects. Additionally, careful attention is given to preserving the neurodevelopmental potential of these patients, as congenital heart disease has been associated with cognitive impairments that can arise from both the condition itself and the stress of surgical interventions. The Yasui procedure is often performed in stages, beginning with an initial palliation followed by a more definitive surgical intervention at a later age. Postoperative management is crucial, and patients typically require rigorous follow-up care to monitor heart function and developmental progress. Since this procedure can be complex, involving intricate anatomical considerations, surgical expertise is paramount for achieving favorable outcomes. Complications may arise, including issues related to shunt obstruction, arrhythmias, and the risk of infection, underscoring the importance of a multidisciplinary approach in managing these patients. Electrophysiological disturbances are of particular concern, and careful monitoring in the postoperative period is essential. Patients undergoing the Yasui procedure often benefit from a coordinated care plan involving cardiologists, surgeons, and specialized nursing teams, ensuring comprehensive support throughout their recovery. As medical technology advances and surgical techniques become more refined, the outcomes for patients undergoing the Yasui procedure continue to improve, offering hope for better quality of life and increased longevity. Ultimately, the Yasui procedure represents a significant advancement in the field of pediatric cardiology, successfully addressing the challenges posed by complex congenital heart defects and paving the way for further innovations in cardiovascular surgery.